Immune
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78 episodes
Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses, gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer https://twitter.com/cindyleifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer https://twitter.com/cindyleifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes. Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer https://twitter.com/cindyleifer, and Brianne Barker Guest: Juliet Morrison Click arrow to play Download Immune 76 (48 MB .mp3, 67 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Guest: Ang Cui Subscribe (free): Apple Podcasts, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation. Hosts: Stephanie Langel, Cynthia Leifer https://twitter.com/cindyleifer, and Brianne Barker Guest: Carla R. Nowosad Subscribe (free): Apple Podcasts, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Ellen Rothenberg Click arrow to play Download Immune 72 (53 MB .mp3, 73 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune explains how, in a mouse model of roundworm infection with , exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection. Hosts: Cynthia Leifer https://twitter.com/cindyleifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Kevin Ng Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus. Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel Download Immune 66 (45 MB .mp3, 76 min) Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Guest: Jonathan C. Kagan http://kaganlab.com/ Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
D’Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Guests D’Broski Herbert http://drherbertlab.org/ Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
From SLB22 on the Island of Hawai’i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Guests: Julia Bohannon and Musa Mhlanga https://mhlangalab.org/ Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Somali and Phil join Immune to discuss their approaches to immunology education. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Guest: Sumali Pandey and Phil Mixter https://twitter.com/philmixter Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be ‘good’ or ‘bad’ in their function. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Guest: Mandy McGeachy Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Guest: Al Singer Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruse Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker http://www.twitter.com/BioProfBarker Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker http://www.twitter.com/BioProfBarker Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer http://www.twitter.com/cindyleifer, and Brianne Barker Guest: Gabriel Victora Subscribe (free): Apple Podcasts, Google Podcasts https://www.google.com/podcasts?feed=aHR0cDovL2ltbXVuZS5saWJzeW4uY29tL3Jzcw%3D%3D. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer http://www.twitter.com/cindyleifer, and Brianne Barker Guest: Nikhil Joshi http://www.nikjoshilab.org/ Subscribe (free): iTunes, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer http://www.twitter.com/cindyleifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer http://www.twitter.com/cindyleifer, and Brianne Barker Guest: Keke Fairfax Subscribe (free): iTunes, Google Podcasts. RSS http://immune.libsyn.com/rss, email Become a patron https://www.microbe.tv/contribute of Immune! LINKS FOR THIS EPISODE __ __ Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv
