The sermon explores the meaning of the Christmas carol "O Little Town of Bethlehem" and its message of God choosing the insignificant and making it significant. It references biblical stories and characters to illustrate this idea. The sermon emphasizes the importance of embracing weaknesses and vulnerabilities, for it is through those moments that God's power can shine. It concludes by inviting listeners to invite Jesus into their lives for healing and redemption, regardless of their past mistakes.