Dr. M's Women and Children First Podcast

Dr. Chris Magryta, "Dr. M"

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Providing listeners with cutting edge science based information for maternal and child health

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405 episodes

Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 11

Measles Overview Again From the CDC: As of this week, there have been 35 cases of measles, the Centers for Disease Control and Prevention (CDC) reported including seven direct importations of measles by international travelers and two outbreaks with more than five cases each. Most of these cases were among children and adolescents who had not received a measles-containing vaccine (MMR or MMRV), even if age eligible. (Site) In 2023, there were 58 total cases. A far cry from the 1274 cases in 2019, but still a sign that risk persists for some unvaccinated and immune compromised people. What is measles - a refresher? Measles is a serious, highly contagious and potentially deadly viral infection. It is caused by an RNA paramyxovirus. It is spread by contact with droplets from an infected person's nose, mouth or throat. Sneezing and coughing can aerosolize the droplets and increase the range of infectious spread. Enjoy, Dr. M

19m
Mar 28
Dr. M’s Women and Children First Podcast #67 – Kate Henry Krese, N.D. – ADHD Part III

Dr. Kate Kresge is the Head of Medical Education at RUPA Health and host of the Root Cause Medicine Podcast. Dr. Kate collaborates with clinicians to bring leading-edge root-cause medicine information to the world through bootcamps, courses, podcasts, articles and more. Before joining RUPA, Dr. Kate was the founding Director of Functional Medicine at Sanare Today, a multi-location practice on the east coast of the U.S. that combines therapy, coaching, natural medicine and more to help people thrive. Dr. Kate’s training in naturopathic medicine began at Bastyr University where she learned how to approach a patient through a prevention focused lens. She focuses on therapies like biofeedback, micronutrient cofactor support and nutrition, allowing her to emphasize root-cause treatments that are both low-cost and effective in order to help keep functional medicine accessible to all. Today, we look at ADHD and the upstream levers that can be pulled on to help reduce the symptom burden. What are the nutritional, lifestyle and other mitigating factors for symptom amelioration? How does Dr. Kate approach a child and the family? What is a meal plan and so much more. Please enjoy my conversation with Kate Kresge. Dr. M

1h 19m
Mar 24
Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 10

APOE4 and the history of human disease Apolipoprotein E, discovered in 1973, is derived from a polymorphic gene called ApoE that encodes for a signaling protein on a class of fatty proteins that primarily carry cholesterol and other molecules around the body. We find ApoE primarily on VLDL, very low-density lipoproteins and HDL, High density lipoproteins. It primarily helps to shuttle cholesterol from the periphery of the body back to the liver. ApoE proteins are also involved in neuronal signaling, neuroinflammation and glucose metabolism making them especially critical for brain activity. This is becoming a critical part of the story for understanding dementia and neurodegeneration. (Williams T. 2020) ApoE is most famous for an isoform, APOE4/4, being highly associated with Alzheimer’s dementia in modernity. Unfortunately, as we do with many things in medicine, we have been focused on this genetic protein variant as a net negative in humans because we look at things as black and white. Either good or bad. A binary choice. Rubish! ..... Enjoy, Dr. M

26m
Mar 22
Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 9

Light and It's Impacts on Health - Circadian Rhythms Circadian comes from the latin Circa Diem or about the day I have long believed that indoor sedentary behavior is profoundly bad for us beyond just the lack of movement and outdoor natural education. Today, we will look at another major concern: light. We will also get into a circadian rhythm post looking at Dr. Panda's work. A final addition of a recipe of the week. Enjoy, Dr. M

19m
Mar 17
Dr. M’s Women and Children First Podcast #20 Reboot – Sandy Newmark, M.D. – ADHD Part II

ADHD without Drugs - This is a reboot of this podcast from 2022 as it aligns with the podcasts of Dr. James Greenblatt and Dr. Kate Henry Sandy Newmark, MD is the Director of Clinical Programs at the University of California at San Francisco's Osher Center for Integrative Health. He is an Integrative Pediatrician and a Professor in the Department of Pediatrics at UCSF with the title of Osher Foundation Endowed Chair in Clinical Programs in Integrative Medicine. To me, he is an amazing teacher and onion peeler in the world of attention deficit. I met Sandy back in 2006 as he was the lead Pediatric teacher in the University of Arizona's Integrative Medicine Fellowship. He immediately made an impact in my career as a leader in this new way of seeing the world of medicine. His bio lists: Dr. Sanford Newmark specializes in integrative neurodevelopmental pediatrics including autism, ADHD, and related conditions. Dr. Newmark lectures widely on both autism and ADHD and has authored three chapters in integrative medicine textbooks. He is the author of the book “ADHD Without Drugs, a Guide to the Natural Care of Children with ADHD.” His online video, “Do 2.5 Million Children Really Need Ritalin? An Integrative Approach to ADHD,” has been viewed over 4.5 million times. Know this, this is an hour of your life that you will want to dedicate to Dr. Newmark's thoughts. Especially, if you or your child has ADHD. Enjoy my conversation with Dr. Newmark, Dr. M

1h 9m
Mar 13
Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 8

Literature Review 1) Cancer is now a unique risk factor for Cardiovascular disease according to recent research. This is being discussed as a point of emphasis for those that have been diagnosed with cancer as the knowledge is a wake up alarm to the biological underpinnings of these disparate immune based diseases. (Melchiori R. et. al. 2023) If you have a strong family history of cancer and heart disease as I do, this data needs to be understood for a prevention lens focus. In a few weeksx I will be discussing APOE genotypes for understanding these realities. 2) In a translational model, sulphurophane increases mitochondrial biogenesis.....Plus a continuous glucose monitor experiment and more from Alison Gopnik's book. Enjoy, Dr. M

17m
Mar 08
Dr. M’s Women and Children First Podcast #66 – James Greenblatt, M.D. – ADHD

{display_podcast] Attention Deficit and Upstream Personalized Treatments This week we sit down with Dr. James Greenblatt, a pioneer in the field of integrative medicine/psychiatry. He obtained his MD and completed his psychiatry residency at George Washington University School of Medicine. This training was followed by a fellowship in child and adolescent psychiatry at Johns Hopkins Medical School. He has been studying and educating providers on functional psychiatry for 4 decades. Dr. Greenblatt has served as the Chief Medical Officer at Walden Behavioral Care in Waltham, MA for nearly 20 years, and is an Assistant Clinical Professor of Psychiatry at Tufts University School of Medicine and Dartmouth College Geisel School of Medicine. His focus is on the scientific evidence for nutritional interventions in psychiatry and mental illness. This is the essence of going upstream to right the wrongs of the biochemical pathways of the brain. He is the author of eight books, including the best-seller, Finally Focused: The Breakthrough Natural Treatment Plan for ADHD. His updated edition of Answers to Anorexia was released in October 2021 and his newest book, Functional & Integrative Medicine for Antidepressant Withdrawal is available now. Dr. Greenblatt is the founder of Psychiatry Redefined, an educational platform dedicated to the personalized, evidence-based treatment of mental health. Psychiatry Redefined offers continuing online education, CME-approved courses, and webinars, and boasts the most comprehensive and scientifically-based professional fellowship for mental health providers, The Psychiatry Redefined Fellowship in Functional & Integrative Psychiatry. Please enjoy my conversation with Dr. James Greenblatt. Dr. M

1h 12m
Mar 03
Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 7

This weeks podcast turned out to be so much more than expected when I first heard about Dr. David Clarke. His work transcends much of what I see in clinic and has given a name to the reality of puzzling chronic illness. From the PPDA website: Psychophysiologic disorders (PPD) are stress-related, brain-generated pain or illness. Even people who handle stress well can have PPD. This occurs when the stress is not fully recognized. The resulting symptoms are completely real. That is why the term we use is a blend of Psychology (the processes of the mind) and Physiology (the processes of the body).....and a discussion on oral allergy syndrome. Enjoy, Dr. M

7m
Feb 28
Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 6

Literature Review 1) Psilocybin is showing further signs of great promise in the fight against depression and PTSD. Psychedelic assisted psychotherapy has gained a foothold in the mainstream of treatment interventions for treatment resistant depression and PTSD. Psilocybin comes from a mushroom that has serotonergic effects on the receptor 5HT2A in the human brain. The results of the studies were net positives in reducing major mood disorder symptoms that are known to be long term in effect. (Haikazian et. al. 2023) I am very excited to see this therapeutic space expand into traumatized teens and other subsets to see outcome benefits. 2) Nanoplastics in the research in the Journal PNAS..... And a section on Antibiotic resistance. Enjoy, Dr. M

17m
Feb 23
Dr. M’s Women and Children First Podcast #65 – Mark Houston, M.D. – Cardiovascular Health

Dr. Mark Houston is a thinker and researcher into the root causes of cardiovascular disease and metabolism. He graduated from Rhodes College in Memphis, Tennessee summa cum laude in Chemistry before graduating with honors from Vanderbilt Medical School. He completed his medical internship and residency at the University of California, San Francisco, then returned to Vanderbilt Medical Center where he was chief resident in medicine and served on the full- time faculty until 2012. He is the current director of the hypertension Institute where he and his team develop novel approaches to hypertension and ASCVD by attending to root biological causes of disease. He also has a Master’s degree in Human Nutrition from the University of Bridgeport, Connecticut, and a Masters of Science degree in Functional and Metabolic Medicine from the University of South Florida in Tampa Florida. He has written hundreds of papers, books and chapters on cardiovascular disease. He is one of the top researchers in the preventative cardiology space and he is here today to share his wisdom. His book credits: Handbook of Antihypertensive Therapy Vascular Biology for the Clinician What Your Doctor May Not Tell You About Hypertension Hypertension Handbook for Students and Clinicians The Hypertension Handbook What Your Doctor May Not Tell You About Heart Disease. Please enjoy my conversation with Dr. Mark Houston, Dr. M Hypertension Institute

1h 10m
Feb 18
Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 5

Sugar, Immune Health and Two Studies Let us start right out of the gate with two studies. #1: Here is the abstract from European Journal of Clinical Nutrition: "Milk contributes with saturated fat, but randomized controlled trials (RCT) on the effects of dairy on the risk of type 2 diabetes (T2D) where dairy is given as whole foods are scarce. The objective of our study was to investigate the long-term effects of semi-skimmed milk on insulin sensitivity and further to compare milk with sugar-sweetened soft drinks (SSSD). A secondary analysis of a 6-month RCT with 60 overweight and obese subjects randomly assigned to 1 L/d of either milk (1.5 g fat/100 mL), SSSD, non-calorie soft drink (NCSD), or water was conducted. Insulin sensitivity was evaluated by oral glucose tolerance test (OGTT) and plasma free fatty acids. Second, fasting blood lipids, blood pressure, and concentration of plasminogen activator inhibitor-1 were assessed......and more on antibiotic resistance. Enjoy, Dr. M

17m
Feb 15
Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 4

Literature Review 1) In an excellent paper by Dr. Harlan and colleagues, we see a group looking at how to modify ultra processed foods to remain tasty for consumption but also healthy. The lead author is Dr. Rob Lustig, a pioneering Pediatric Endocrinologist from UCSF and upcoming podcast guest. From the paper: "Ultraprocessed food is established as a metabolic disruptor acting to increase adiposity, reduce mitochondrial efficiency, drive insulin resistance, alter growth, and contribute to human morbidity and mortality. Consumer packaged goods (CPG) companies are beginning to understand the detrimental impact of the food they market, and have employed substitution strategies to reduce salt, sugar, and fat. However, the harms of ultraprocessed foods are far more complex than any single component, and are not ameliorated by such simple substitutions." (Harlan et. al. 2023)......as well as information on Why ask why? and a recipe of the week. Enjoy, Dr. M

14m
Feb 10
Dr. M’s Women and Children First Podcast #64 – Dan Shapiro, Ph.D. – Provider Burnout

Dan Shapiro is a man on a mission to help physicians, other providers and the medical healthcare administrators understand the reality of healthcare provider burnout. He is currently the Director of the Chartis Center for Burnout Solutions, where he and his team assist leaders of multi-hospital systems with efforts to reduce burnout and the turnover of high-value physicians, nurses, advanced practice providers, and other staff. Dan’s education goes back to my alma mater, Vassar College. He graduated with a BA in Psychology before going to the University of Florida for his doctorate in clinical psychology. He completed a post doctoral degree in Medical Crisis Interventions at Harvard University. He held faculty positions at the University of Arizona as well as at Penn State rising to the Chair and Professor of Humanities at Penn State College of Medicine. In 2017, he developed a systematic method for assessing and addressing burnout leading to consulting services focused on multi-hospital systems. In 2023, he left his role as Vice Dean and Chair to pursue the reduction of burnout full time with colleagues at Chartis. Dan is a frequent contributor to thought leadership in the physician burnout space. In 2003, Random House published his landmark memoir about one physician’s burnout, titled, “Delivering Doctor Amelia,” which was required reading at some colleges and medical schools. He’s written two other books, also for Random House. Dan’s additional writings have appeared or been featured in, among others, the New York Times, Proceedings of the National Academies of Science, the New England Journal of Medicine, JAMA, Academic Medicine, and NPR’s All Things Considered. As a hobby, he worked for ten years as a weekly consultant to the hit television shows Grey’s Anatomy, Private Practice, How to Get Away with Murder and on-camera for the Discovery, National Geographic, and FYI channels. Please enjoy my conversation with Dan Shapiro, Dr. M

1s
Feb 06
Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 3

Resolutions? Do we need them? The simple answer for me is this - if it causes beneficial change, then yes we need them. Ideally, change should occur real time as the need or knowledge of benefit becomes apparent. New Years is traditionally a time that we introspect and set new goals for a better life. What that means to each one of us is as varied as the plants that exist, save for human health. We all WANT to be healthy. We all WANT to be happy. The impediment to being is not changing.....plus audience questions answered and a recipe of the week. Enjoy, Dr. M

13m
Feb 03
Dr. M’s Women and Children First Podcast #63 – David Clarke, M.D. – Pain, Psychology and Trauma

This weeks guest is Dr. David D. Clarke. Dr. Clarke is President of the Psychophysiologic Disorders Association where he teaches the science of the mind body connection as it relates to GI related diseases that do not fit a traditional diagnostic nor pathological framework. For three plus decades, he conducted detailed interviews with over 7000 people whose symptoms were not explained by diagnostic testing, but were significantly affecting their lives in a negative way. He realized that these individuals often suffered from severe traumas in childhood that built the foundation of current health struggles. We dive into his work and the successes built upon the recognition of, intervention for and resolution related to the issues and physiological manifestations of disease. Dr. Clarke graduated from Williams College with honors before attending the University of Connecticut School of Medicine where he received his medical degree and the Mosby Award for Clinical Excellence.  He completed internship and residency in Internal Medicine and fellowship in Gastroenterology at Harbor/UCLA Medical Center in Los Angeles. Dr. Clarke has lectured extensively on Psychophysiologic Disorders to specialists and the public across North America and Europe. He has appeared on syndicated broadcasts hosted by Rosie O'Donnell, by Montel Williams and by Michael Roizen(author of You: The Owner's Manual). He is the Author of "They Can't Find Anything Wrong" and co-author of "A Diagnostic Guide for Psychophysiological Disorders" and Psychophysiologic Disorders". Please enjoy my conversation with Dr. David Clarke, Dr. M

1s
Jan 27
Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 1

Literature Reviews have been very popular. Thus, 2024 will start with science update. 1) Time restricted eating patterns are known to help physiology and metabolism by initiating a pause in the action of mTOR and muscle synthesis as well as inducing autophagy. Autophagy is critical to the clearance of broken or damaged cells following injury or disease. How does circadian biology play into this reality? From Cell Metabolism: "Circadian disruptions impact nearly all people with Alzheimer’s disease....plus a discussion on water, dehydration and prevention as well as a recipe of the week. Enjoy, Dr. M

16m
Jan 23
Dr. M’s SPA Newsletter Audiocast Volume 14 Issue 2

Christmas, Tradition and Holidays in General. When I think about the holidays, I think about large family gatherings, fake birds chirping in the Christmas tree, my Babcia cooking pierogis in butter, bacon and onions and serving me a huge plate, my cousin tripping and falling into the tree trying to turn off the chirping bird. I think of Christmas eve singing Polish and English carols. I remember the long table with 30 people sitting around the room celebrating togetherness. Life was pure as a child. Being the youngest of the generation, I seemed to see everything from the lowest viewpoint. I heard everything that was said that may or may not have been appropriate.......................plus a piece on genes and mental health. Recipe of the week is here as well. Enjoy, Dr. M

10m
Jan 23
Dr. M’s Women and Children First Podcast #62 – Jeff Bland, Ph.D. – The Disease Delusion and Hope for Change

Podcast #62 Jeff Bland, Ph.D. This week I have the absolute pleasure to introduce you to Dr. Jeff Bland. He is in a word, incredible. Dr. Bland is supreme thinker in the field of medicine and biology. He is a teacher, product developer, thought leader, unifier of minds and so much more. He obtained his BS in Biology at the University of California at Irvine and then a PhD from the University of Oregon. Dr. Bland was thinking about medicine from a root cause perspective decades before it became more vogue to believe in Integrative medicine. He is the founder of the Institute for Functional Medicine as well as his new company Big Bold Health, a company on a mission to transform the way people think about one of nature’s greatest innovations — the immune system. With Big Bold Health, he is pushing for the power of cellular immuno-rejuvenation through food to enhance immunity at a human level. The key is the rediscovery of ancient food crops and superfoods that have these properties of health promotion. We wander the landscape of human health through bramble and brook without a care in the world. It is a most enjoyable conversation to share. Enjoy, Dr. M

1h 17m
Jan 14
Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 52

What have I learned over the last 13 years? 1) That medicine is an onion peel that never ends! We keep learning and evolving into newer and more mature ways to understand the physiology of balance in all things human. When in balance, disease is stymied. When not so balanced, disease has a chance to start and flourish. After interviewing 68 guests, one common theme has arisen - that we have a layer of control to prevent disease and strife that is huge when young and gets smaller and less nimble as we age. Thus, prevention remains the best source of therapy for the human species to overcome the current negative trajectory on human health. Starting at the individual level appears to be the best answer as the collective, especially in government, is not aligned with health. When many of the most wealthy companies are insurers, hospitals and pharmaceuticals, we have our incentives upside down. The wealth should pour into companies preventing illness.......

27m
Jan 09
Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 51

Literature Review 1) High resting cardiac vagal tone or control, CVC, is associated with more flexible emotional responding to external stressful stimuli. With regard to vagal changes the evidence shows us that stress will decrease CVC . (Balzarotti et. al. 2017) Being relaxed and not stressed out is always associated with better cellular physiology. CVC is a marker of relaxation and thus emotional control. Whenever you find yourself emotionally dysregulated, there is a good chance that your vagal tone is off. Work to meditate, exercise and relax which will increase CVC and help you cope. 2) Continuing on the same theme..... plus a discussion on maternal neural hormonal rewiring, and a recipe of the week.

14m
Jan 04
Dr. M’s Women and Children First Podcast #61 – Bridget Briggs, M.D. – Hope and Epigenetics Part 3

This is the third story of hope for us as a species. We have a level of control over our outcome that is baked into our DNA. Bridget R. Briggs, M.D. and I sit down today to discuss the clinical approach to epigenetics in patients especially women. She is a physician who specializes in Women’s Health. Dr. Briggs received her undergraduate degree from the University of California Los Angeles in Psychobiology. She then completed her medical degree from University of California San Diego School of Medicine before completing her residency in family medicine as well as internship in Obstetrics and gynecology. She has been in practice for 25 years in Southern California. She is the owner of two family medicine practices in California where she specializes in functional medicine and womens health. She is a well known speaker and educator on the topics of epigenetics and methylation in humans. Her story is personal regarding her deep dive into epigenetics and health based on her family's history and experiences to date. We take a winding road looking at the clinical applications of epigenetic understandings as laid out by the experts and trailblazers of DNA methylation and phenotypic change in animals and humans. We get into some controversial topics including vaccination, preparation for, avoidance of and much more. The conversation is open, honest and thoughtful. We finish with a hard look at the pregnancy state and how to achieve optimal outcomes for our offspring. It is another story of hope for humanity. Please enjoy my conversation with Dr. Bridget Briggs, Dr. M

1h 12m
Jan 01
Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 50

Literature Review 1) Pericytes are critical cells that sit around the tiny blood vessels called capillaries of the body especially in the brain. They are involved in regulating blood vessel activity. They communicate directly with the endothelial cells making them super important in the activity of the blood vessel and metabolism at the local tissue interface. From the journal Cell Death and Disease we see: "Crosstalk mechanisms....And some other discussions on Cancer detection at physicals as well as the recipe of the week. Enjoy, Dr. M

14m
Dec 29, 2023
Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 49

Respiratory Syncytial Virus RSV is a 150 nanometer RNA virus that comes from a human orthopneumovirus that circulates in the winter primarily. Young children and infants infected with RSV mostly have upper respiratory tract symptoms where a subset develop lower respiratory tract disease known as bronchiolitis with the primary infection. It is the most common reason for hospitalization in infants between 0 and 6 months of age. Bronchiolitis appears as a wheezy, cough centric illness that rarely may progress to increased respiratory effort noted by wheezing, rales (lung crackles - sounds like stepping on leaves), chest wall rib retractions, grunting, fast breathing, nasal flaring and eventually respiratory hypoxia. If it persists, the event can rarely lead to respiratory collapse and death. Annually, 150 children under 5 years of age die from RSV in the US. Most of these children are premature births and have cardiopulmonary disease issues. Term healthy children rarely succumb to RSV in a serious way. A recent study of German infants and children hospitalized with RSV identified these risk factors: age

16m
Dec 25, 2023
Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 48

Covid 19 Post Mortem Part II The story of the Standard American Diet and its directional connection to death from Sars2 - Covid. Post Covid population health data has shown us that humans that chronically consume more meat, sugar, animal products and highly processed foods were associated with more death and morbidity if they contracted early versions of Covid19. The effect of consuming sugar products on mortality was considerable, and obesity has affected increased death rates and reduced recovery rates. (Kamyari et. al. 2021) (Greene et. al. 2021) (Merino et. al. 2021) - also a Recipe of the Week. Enjoy Dr. M

47m
Dec 20, 2023
Dr. M’s Women and Children First Podcast #60 – Moshe Szyf, Ph.D. – Hope and Epigenetics Part 2

This week's guest is Professor Moshe Szyf. This is the second story of hope for us as a species. We have a level of control over our outcome that is baked into our DNA. Dr. Moshe Szyf joins the show today to discuss the social programming of the epigenome. Dr. Szyf and his colleague Dr. Meaney proposed over two decades ago the first set of evidence that the “social environment” early in life can alter DNA methylation launching the emerging field of “social epigenetics”. He also has illustrated that DNA methylation is a prime therapeutic target in cancer and other diseases to be explored and potentially manipulated for health. "Together, they discovered that our genetic code, the actual sequential structure of our DNA, can pretty much shrug off the influence of any external environmental factors, short of massive radiation. However, the expression of individual genes within that sequence can be permanently altered by such seemingly innocuous influences as diet or how others treat us. Once triggered, a group of molecules called a methyl group attaches itself to the control centre of a gene, permanently switching on or off the manufacture of proteins that are essential to the workings of every cell in our body. In most tumours, this DNA methylation pattern has been knocked awry, leading to a gene being completely deactivated or triggered to abnormally high activity." (McGill Reporter) Dr. Szyf received his Ph. D from the Hebrew University and did his postdoctoral fellowship in Genetics at Harvard Medical School before he joined the department of Pharmacology and Therapeutics at McGill University in Montreal, Canada. He currently holds the James McGill Professorship in Pharmacology. He is the founding co-director of the Sackler Institute for Epigenetics and Psychobiology at McGill and is a Fellow of the Canadian Institute for Advanced Research Experience-based Brain and Biological Development program. Szyf has been the founder of the first “Pharma” to develop epigenetic pharmacology “Methylgene Inc.” and the first journal in epigenetics “Epigenetics”. Please enjoy my conversation with Dr. Moshe Szyf, Enjoy, Dr. M

57m
Dec 16, 2023
Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 47

Covid 19 Post Mortem As you all know, after reading countless articles that I have posted about COVID and the policies that were put in place by "well meaning" bureaucrats, I have been highly critical of the events that took place and the US Government's failure on so many fronts. There are two seminal articles that have been written on these topics to date: 1) COVID-19 Origins: Investigating a “Complex and Grave Situation” Inside a Wuhan Lab, 2) COVID Lockdowns Were a Giant Experiment. It Was a Failure. A key lesson of the pandemic. 3) The third and equally critical article that remains unpublished is the story of the Standard American Diet and its direct connection to death from Covid.....also conversations on picky eaters and a recipe of the week. Enjoy, Dr. M

19m
Dec 12, 2023
Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 46

Delaying Gratification and Dopamine When we think of our current societal view on raising children, we have a conundrum. We want our children to experience the world as it is progressing through a technological viewpoint, a growth mentality. What does that mean? . When technology enters the learning process, we progress at log rates. We can process more information and incorporate it into our memory. For a simple example, let's look back in time. When I was in school, I had to go to the library and search through the library's archaic dewey decimal system to find a book to reference for information for a project or assignment. Time wasting to say the least compared to the internet age. It took forever to accumulate old data that was in a book. No real time action...Also a mini literature review and a recipe of the week. Enjoy, Dr. M

1s
Dec 07, 2023
Dr. M’s Women and Children First Podcast #59 – Randy Jirtle, Ph. D. – The Imprintome and Hope

Randy Jirtle, Ph.D. This week's guest is Professor Randy Jirtle. Dr. Randy Jirtle joins the show for the second time today to discuss his new research on the imprintome, the regulatory regions that at the earliest stages of fetal development control our epigentic and thus our genetic outcome. This is the Hope locus. Time Magazine nominated him for person of the year in 2007 and had this to say about him: “Dr. Jirtle’s pioneering work in epigenetics and genomic imprinting has uncovered a vast territory in which a gene represents less of an inexorable sentence and more of an access point for the environment to modify the genome. His trailblazing discoveries have produced a far more complete and useful understanding of human development and diseases” — Time Magazine. This interview is ground zero for the Women and Children First Podcast as we discuss the underpinnings or mechanisms of disease risk for all humans as it relates to the environmental inputs of our lives that are driving health or disease at both the pregnancy and post natal periods. We look specifically at how maternal nutrition and later chemical exposure directly affected the health of the agouti mouse offspring. This experiment was the first of its kind and paved the way for a complete shift in human disease understanding. For parents, this podcast is really the beginning of everything that I am trying to convey regarding a healthy pregnancy and childhood. Without this interview, the following interviews will be more difficult to understand. The picture becomes very clear once his research is cemented in our minds. His biography is as follows: Professor of Epigenetics at the Department of Biological Sciences, North Carolina State University, Raleigh, NC, and a Senior Scientist at McArdle Laboratory for Cancer Research at the University of Wisconsin, Madison, WI. He was previously professor of radiation oncology and associate professor of pathology at Duke University, Durham, NC, where he had been a faculty member since 1977. He graduated with a B.S. degree in nuclear engineering in 1970 and a Ph.D. degree in radiation biology in 1976, from the University of Wisconsin-Madison. His awards list is long but the key to Dr. Jirtle is that he is a curious thinker and we are grateful for this. Please enjoy my conversation with Dr. Randy Jirtle, Enjoy, Dr. M

1h 22m
Dec 04, 2023
Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 45

Nature Deprivation Disorder: As we are getting closer to the end of the year and the cold strikes us hard in the face, we have a tendency to hunker down indoors and avoid the outside. Video games and screens are omnipresent in many of our children's lives. They pervade their thoughts. They significantly limit their self-driven need and desire to explore, imagine and be present with nature, silence and life as it exists around them. Nature and natural actions are some of the best teachers of rational action and normalcy in any ecosystem....Autism etiology and a recipe round out the week. Enjoy, Dr. M

11m
Dec 01, 2023
Dr. M’s SPA Newsletter Audiocast Volume 13 Issue 44

In a Nature study by Dr. Chassaing and colleagues we see a data set raising a legitimate concern regarding synthetic emulsifiers. Let us look at the title, dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome.....Emulsifiers are the topic today. Also, some information with a mini literature review and a discussion on power struggles.   Enjoy, Dr. M

18m
Nov 28, 2023