During the 2023 American Association of the Study of Liver Diseases (AASLD) conference, exciting and important results from many primary biliary cholangitis (PBC) clinical trials were reported, including 3 late-breaking studies on the PPAR-delta agonist seladelpar, the dual PPAR agonist elafibranor, and the combination of the FXR agonist obeticholic acid and a fibrate.

In this episode, Marlyn J. Mayo, MD, discusses topline results from several of these studies and more, including: 

• A phase III study of an investigational dual PPAR α/δ agonist (elafibranor) in people with PBC who did not respond to or were intolerant of ursodeoxycholic acid (UDCA)
• A study that evaluated the effectiveness and safety of second-line therapy in PBC where obeticholic acid with or without a fibrate was added to the treatment regimen of people with PBC with an incomplete response to UDCA
• A retrospective review of the rates of hyperlipidemia, atherosclerosis, and/or hepatic steatosis in patients with PBC

Presenter: 

Marlyn J. Mayo, MD
Professor of Internal Medicine
Division of Digestive & Liver Diseases
UT Southwestern Medical Center
Dallas, Texas

Link to commentary:
Coming Soon!

Link to reviews of other PBC studies from AASLD 2023: 
https://bit.ly/3RvXXEI