In this episode of the IJGC podcast, Editor-in-Chief, Dr. Pedro Ramirez, is joined by Dr. Giuseppe Caruso discuss post-PARP myeloid neoplasms. Dr. Caruso is a fifth-year resident in Obstetrics and Gynecology and a first-year fellow of the PhD in “Network Oncology and Precision Medicine” at Sapienza University of Rome in Italy. Over the past year, he has been attending the Department of Gynecologic Oncology at the European Institution of Oncology (Milan) under the mentorship of Professor Nicoletta Colombo and has now started his research fellowship period at Mayo Clinic (Rochester) under the supervision of Professor William Cliby. His main interest areas are gynecologic oncology, personalized oncology, and clinical research.

Highlights:

- Myeloid neoplasms post PARPi in patients with ovarian cancer are gradually emerging as life-threatening late toxicities and should not be underestimated.

- The first two years of PARPi exposure are the critical window of onset and persistent cytopenia has been recognized as an early warning sign.

- Active surveillance, differential diagnosis, and prompt hematological referral are crucial.

- PARPi are recommended in the first line also to improve the risk-benefit ratio.

- PARPi should be used cautiously in patients with a higher baseline risk and/or those who are less likely to have a significant benefit.