Pharmacy to Dose: The Critical Care Podcast
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143 episodes
Final Four Preview and More: 2024 Critical Care Trials March Madness Bracket Sepsis/Fluids Bracketologist: Clay Small, PharmD, BCCCP CV/Pulm Bracketologist: Jolie Gallagher, PharmD, BCCCP Bleeding/BG Bracketologist: Jason Hecht, PharmD, BCPS, BCCCP, FCCM Neuro/PADIS Bracketologist: Karen Berger, PharmD, FASHP, FCCM, BCPS, BCCCP 06:10 – Region recaps 32:10 – Final Four preview and predictions 45:30 – Revisiting pre-tournament predictions PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf Listener Bracket: https://pharmacytodose.com/2024/04/01/final-four-2024-critical-care-trials-march-madness-bracket-preview-and-recap/ 2024 Critical Care Trials March Madness blank bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Literature Review Series October 2023 Special Guests: Hailey Burns, PharmD @Hailey_rx36 Caitlyn Simonson, PharmD 03:45 – Featured Articles 38:15 – Neuro 50:10 – EM/Tox/Trauma 61:50 – Renal/Endocrine 66:38 – PharmD 70:10 – Sweet Emotion Reference List: https://pharmacytodose.files.wordpress.com/2024/03/october-lrs-2023-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Sweet 16 Preview and Recap: 2024 Critical Care Trials March Madness Bracket Preview 04:06 – First round recap 13:25 – Second round recap 19:05 – Sweet 16 preview PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf 2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Pharmacotherapy in the Critically Ill Pregnant Patient: Part II Special Guests: Allison Lankford, MD Melissa Thompson Bastin, PharmD, PhD, BCCCP, FCCM, FCCP @mtbastin 04:50 – Obstetric hemorrhage 18:20 – Ectopic pregnancy 22:30 – Hypertensive emergency 28:45 – Pre-eclampsia/eclampsia 35:00 – Lactation considerations 39:35 – Take-home points Pharmacotherapy “Caring for two in the ICU” articles: Part I: https://pubmed.ncbi.nlm.nih.gov/36938691/ Part II: https://pubmed.ncbi.nlm.nih.gov/37323102/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
2024 Critical Care Trials March Madness Bracket Preview: Part II Cardiac/Pulmonary and Sepsis/Fluids Regions CV/Pulm Bracketologist: Jolie Gallagher, PharmD, BCCCP Sepsis/Fluids Bracketologist: Clay Small, PharmD, BCCCP PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf 2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
2024 Critical Care Trials March Madness Bracket Preview: Part I Bleeding/Blood Glucose and Neuro/PADIS Regions Bleeding/BG Bracketologist: Jason Hecht, PharmD, BCPS, BCCCP, FCCM Neuro/PADIS Bracketologist: Karen Berger, PharmD, FASHP, FCCM, BCPS, BCCCP @karenccrx PubMed links for all 68 Critical Care March Madness trials: https://pharmacytodose.files.wordpress.com/2024/03/critical-care-trials-reference-list-all-regions.pdf 2024 March Madness Bracket: https://pharmacytodose.com/2024/03/17/2024-critical-care-trials-march-madness-bracket/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Trial of the Week: CHAMPION PHOENIX Special Guest: Jack Pluenneke, PharmD, BCCP @JackPluenneke Jack Pluenneke joins to discuss a March 2024 Trial of the Week, “Effect of platelet inhibition with cangrelor during PCI on ischemic events” the CHAMPION PHOENIX trial, published in 2013 in NEJM. We review PK/PD advantages with cangrelor, go over the CHAMPION trials, and then highlight why the CHAMPION PHOENIX trial was necessary. Then we dive into the Trial of the Week: CHAMPION PHOENIX trial and discuss its findings as well as study design. Are these patients we’d see in our ICU? How does cangrelor compare to glycoprotein 2b/3a inhibitors? Is it a weakness that the comparator group uses clopidogrel? The episode closes with medication safety considerations, cangrelor’s place in therapy, and much more. Reference list: https://pharmacytodose.files.wordpress.com/2024/03/champion-phoenix-trial-of-the-week-references-1.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Corticosteroids in the Critically Ill Special Guest: Andrea Nei, PharmD, BCPS, BCCCP, FCCM @Dre_pharmd 04:40 – Guideline introduction/background 08:35 – Scope/authorship 13:35 – PICO questions/recommendations 14:22 – Sepsis 17:20 – CAP 19:10 – ARDS 21:55 – Research priorities/Take-home points 28:50 – Working with your spouse Learn more about your ad choices. Visit megaphone.fm/adchoices
Trial of the Week: REDUCE Special Guest: Matt Duprey, PharmD, PhD, BCCCP Matt Duprey joins to discuss the March Trial of the Week, published in 2018 in JAMA: “The Effect of Haloperidol on Survival Among Critically Ill Adults with a High Risk of Delirium: the REDUCE Randomized Clinical Trial.” We review the history of antipsychotic pharmacotherapy treatment and prophylaxis in delirium, reviewing guideline recommendations from that time. Then we dive into the Trial of the Week: REDUCE trial and discuss its findings as well as study design. Would results be the same with another medication? Why is delirium research so challenging? Prevalent v. incident delirium? What’s the best outcome to measure? What questions still need answered? These questions and so much more are answered in today's episode. Reference list: https://pharmacytodose.files.wordpress.com/2024/03/reduce-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Pharmacotherapy in the Critically Ill Pregnant Patient: Part I Special Guests: Allison Lankford, MD Melissa Thompson Bastin, PharmD, PhD, BCCCP, FCCM, FCCP @mtbastin 08:05 – PK/PD changes 12:50 – Medication safety/Drug information resources 20:15 – Maternal sepsis 33:15 – ARDS 43:15 – PADIS 48:45 – Cardiogenic shock & cardiac arrest 59:00 – VTE Pharmacotherapy “Caring for two in the ICU” articles: Part I: https://pubmed.ncbi.nlm.nih.gov/36938691/ Part II: https://pubmed.ncbi.nlm.nih.gov/37323102/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Trial of the Week: Levetiracetam Rapid IV Push Special Guest: Olivia Morgan, PharmD, BCCCP, BCGP I’m joined by Olivia Morgan to discuss her first author 2020 Neurocritical Care article entitled “Safety and Tolerability of Rapid Administration Undiluted Levetiracetam.” We review previous administration techniques and discussing how this study came to be before highlighting all the findings from this Trial of the Week. Then we discuss how the protocol has changed since this study, administering other ASM via rapid IV push, and much, much more. Reference list: https://pharmacytodose.files.wordpress.com/2024/03/keppra-rapid-ivp-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Glycemic Control in the Critically Ill: Part I Special Guest: Traci Grucz, PharmD, BCCCP @tmgrucz 04:50 – ICU hyperglycemia mechanism 09:52 – Background/landmark research 27:00 – Current recommendations 30:25 – Hyperglycemia and hypoglycemia tips/tricks 46:30 – Treatment considerations 54:50 – Take-home points Reference List: https://pharmacytodose.files.wordpress.com/2024/02/glycemic-control-in-the-icu-part-i-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Literature Review Series September 2023 Special Guests: Garrett Terhune, PharmD Caroline Blankemeier, PharmD 04:35 – Featured Articles 32:28 – Pulm 38:35 – PADIS 46:50 – Neuro 53:40 – Trauma 62:00 – PharmD 68:10 – Grab Bag Reference List: https://pharmacytodose.files.wordpress.com/2024/02/september-lrs-2023-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Immunotherapy Part II Special Guest: Matt McKenzie, PharmD, BCCCP @mgm485 04:40 – What is and when do we use immunotherapy? 09:00 – CAR-T cell therapy 15:20 – Standard ICU work-up 21:00 – Cytokine release syndrome (CRS) 35:00 – Immune effector cell-associated neurotoxicity syndrome (ICANS) 51:00 – Immune checkpoint inhibitors 64:30 – Summary and take-home points Reference List: https://pharmacytodose.files.wordpress.com/2024/02/immunotherapy-part-ii-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Burnout and Well-being Special Guest: Brent Reed, PharmD, MS, PhD Candidate 07:25 – How did we get here? 09:05 – Defining and drivers of burnout 18:45 – Is it too late if we're already experiencing? 20:15 – Relationship between well-being and burnout 22:00 – Work:life balance 29:00 – Precepting and teaching 35:25 – Foundation of burnout prevention 38:30 – 5 step process for work design change 50:50 – Being proactive and short-/long-term fixes Reference List: https://pharmacytodose.files.wordpress.com/2024/02/burnout-and-well-being-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Literature Review Series August 2023 Special Guests: Katie Rogers, PharmD Eric Johnston, PharmD 04:35 – Featured Articles 39:00 – Sepsis 47:35 – Potpourri 52:45 – Infectious Diseases 61:45 – PharmD 68:15 – Grab Bag Reference List: https://pharmacytodose.files.wordpress.com/2024/01/august-lrs-2023-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
2024 SCCM Congress Recap Special Guest: Anthony Hawkins, PharmD, FCCM, BCCCP Conference correspondent Anthony Hawkins returns to recap all the happenings from the 2024 SCCM Congress. We review Phoenix, likes and dislikes from the Convention Center, session highlights, exhibit hall review, favorite session titles, PharmD award winners, and much, more. 2024 SCCM Congress website: https://congress2024.sccm.org PharmacyToDose.com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
2024 SCCM Congress: Tuesday Special Guests: Karen Berger, PharmD, FASHP, FCCM, BCCCP, BCPS Melanie Smith Condeni, PharmD, FCCM, BCPS, BCCCP Julie Farrar, PharmD, BCCCP Lama Nazer, PharmD, BCPS Joanna Stollings, PharmD, FCCP, FCCM, BCPS, BCCCP Andy Webb, PharmD, BCCCP 03:05: Star Research Presentation: “Effect of Antipsychotics on Agitation in ICU Delirium: Secondary Analysis of a Randomized Trial” featuring Joanna Stollings 10:43: Star Research Presentations: “Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients with Sepsis (PRO-CAN)” & “Diagnostic and Prognostic Value of Procalcitonin in Critically Ill Cancer Patients with Sepsis” featuring Lama Nazer 25:32: Clinical Pharmacy and Pharmacology (CPP) Year in Review presenter and moderator roundtable discussion featuring Karen Berger, Melanie Smith Condeni, Julie Farrar, and Andy Webb 2024 SCCM Congress website: https://congress2024.sccm.org PharmacyToDose.com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
2024 SCCM Congress: Monday Special Guests: Caitlin Brown, PharmD, BCCCP, FCCM Marilyn Bulloch, PharmD, BCPS, FCCM Kayla Kotch, PharmD, BCCCP 02:55: Marilyn Bulloch discusses her role and experience as a 2024 SCCM Congress co-chair 28:30: Star Research Presentation: “Impact of Early Initiation of Phenobarbital for Alcohol Withdrawal Syndrome in the Critically Ill” featuring Kayla Kotch 39:00: Star Research Presentation: “A Multicenter Study of Pulmonary Embolism Patients Treated with Reduced- or Full-Dose Alteplase” featuring Caitlin Brown 2024 SCCM Congress website: https://congress2024.sccm.org PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
2024 SCCM Congress: Sunday Special Guests: Judi Jacobi, PharmD, BCCCP, MCCM Blake Robbins, PharmD, MBA, BCCCP 02:45: Quick review of the happenings on Sunday, January 21st from 2024 SCCM Congress 07:20: Star Research Presentation: “Standard vs. Augmented Corticosteroid Dosing in Mechanically Ventilated Patients due to COVID-19” featuring Blake Robbins 22:05: Discussion about the SCCM Glycemic Control in the ICU featuring Judi Jacobi Glycemic control guidelines: https://journals.lww.com/ccmjournal/fulltext/9900/society_of_critical_care_medicine_guidelines_on.277.aspx Star research presentation: https://journals.lww.com/ccmjournal/pages/articleviewer.aspx?year=2024&issue=01001&article=00030&type=Fulltext PROPHY-VAP: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00471-X/fulltext 2024 SCCM Congress website: https://congress2024.sccm.org PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
2024 SCCM Congress: Saturday The episode starts out with a preview of the 2024 SCCM Congress schedule as the conference starts Sunday, January 21 in Phoenix, AZ 11:25: Then I highlight 3 presentations with Pharmacist speakers from the SCCM Digital Congress Fill the Tank or Squeeze the Pipes? Fluid Administration Over Early Vasopressor Therapy for the Management of Shock with Olivia Marchionda, PharmD, BCCCP Anticoagulation Considerations in Critically Ill Oncology Patients with Heather May, PharmD, MSc, BCCCP, FCCM Pharmacologic Agents Used in the ICU for Palliation of Symptoms: What’s New? With Nicole Palm, PharmD, BCCCP, FCCM 2024 SCCM Congress website: https://congress2024.sccm.org PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
ACORN: Rapid Reaction Special Guests: Michael Behal, PharmD, BCCCP Joanna Stollings, PharmD, FCCP, FCCM, BCPS, BCCCP Michael Behal joins me to review the recently published ACORN trial from JAMA. We highlight the background of antibiotic-associated AKI, review the trial methodology and results, dive into the supplement and talk about duration of treatment, empiric v. targeted treatment, have definitively answered this question or not, and much more. Joanna Stollings makes a special appearance highlighting her experience on the research group while also discussing the logistics of this innovative trial design. Reference List: https://pharmacytodose.files.wordpress.com/2024/01/acorn-rapid-reaction-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Pharmacy to Eat: Food Recommendations and Life Update HAPPY THANKSGIVING! 03:19 – Indianapolis: Nick Peters 04:50 – Boston: Grace Erdman 05:55 – New Haven: Steve Lemieux and Kelly Oldziej 08:30 – Buffalo: Nick Servati 10:33 – New York: Karen Berger and Peter Nikolos 12:58 – Philadelphia: Ashley Barlow, Brooke Barlow, Sara Groome, Alyssa Meester, and Todd Miano 19:31 – Maryland: Mojdeh Heavner and Amy Yeung 21:38 – Charleston: Melanie Smith Condeni 24:07 – Memphis: Morgan Jones 26:18 – Cincinnati: Chris Droege 30:00 – Chicago: Matt Rubertus 31:35 – Detroit: Zach Smith 32:57 – Texas: Josiah Smith and Matt Wanat 36:25 – Europe: Philip Jacobson 38:12 – Favorite meals: Brian Gilbert and Haley Peters 41:02 – Life update https://pharmacytodose.com/2023/11/23/pharmacy-to-eat-food-recommendations/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
2023 ACCP Annual Meeting Recap Conference Correspondent: Anthony Hawkins, PharmD, FCCM, BCCCP Anthony’s travel day, Dallas airport comparison and city review, poster hall likes/dislikes, unique and notable clinical sessions, favorite titles, Critical Care PRN business meeting highlights, award winners, FCCP awardees, correcting a last name mispronunciation, #MakePharmacyLessFormal and much more. https://pharmacytodose.com/2023/11/22/2023-accp-annual-meeting-recap/ PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
2023 ACCP Annual Meeting Day 1 & 2 Mini Recap Nick discusses his highlights, thoughts, and even suggestions from Day 1 & 2 of the 2023 ACCP Annual Meeting in Dallas, TX. https://www.accp.com/meetings/am23/index.aspx @PharmacyToDose PharmacyToDose@Gmail.Com PharmacyToDose.com Learn more about your ad choices. Visit megaphone.fm/adchoices
AVP: All Vasopressin Podcast Special Guests: Seth Bauer, PharmD, FCCM, FCCP, BCCCP Gretchen Sacha, PharmD, BCCCP 05:42 – Historical use/mechanism of action 14:00 – Septic shock guideline recommendations 18:45 – When to add vasopressin? 26:55 – Vasopressin dosing 38:52 – Predicting vasopressin response 48:55 – Use in special populations 61:25 – Discontinuation 67:39 – Cost considerations 72:48 – Use in other shock states 77:00 – Future research/Take-home points Reference List: https://pharmacytodose.files.wordpress.com/2023/11/avp-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Trial of the Week: Rivers EGDT in Sepsis Special Guest: Rob Maclaren, PharmD, MPH, MCCM, FCCP I’m joined by Rob Maclaren to discuss the 2001 NEJM study “Early goal-directed therapy in the treatment of severe sepsis and septic shock.” We discuss the historical care of sepsis, mortality rates prior to this study, and use of critical care bundles before highlighting all the findings from the Rivers EGDT in sepsis trial. Then we review if one component is more important than others, break down the bundle, is EGDT still recommended, and much, much more. Reference list: https://pharmacytodose.files.wordpress.com/2023/11/rivers-egdt-tow-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
2023 North American Congress of Clinical Toxicology (NACCT) Pharmacist-featured Research Highlights 02:36 – “Association between daily high temperature and copperhead envenomations reported to a regional poison center” ft. Jimmy Leonard, PharmD, DABAT 18:22 – “Persistent complications following snake envenomation: results of a specialized snake post-discharge clinic” ft. Erin Ryan, PharmD 31:56 – “Evaluation of large-scale, interactive simulation in poison management & drug abuse course” ft. Kristin Reinaker, PharmD, DABAT 44:43 – “A systematic review of phenibut withdrawal with a focus on complications, treatment strategies, and phenibut alone or polysubstance withdrawal” ft. Ryan Feldman, PharmD, BCPS, DABAT 61:33 – “Evaluation of the carbapenem-valproate interaction” ft. Nick Petrucelli, PharmD 70:40 – “The use of ertapenem for reducing toxic valproic acid concentrations” ft. Patrick Dougherty, PharmD, BCPS, BCEMP Link to view research poster PDFs: https://pharmacytodose.com/2023/11/03/2023-nacct-pharmd-research-highlights/ @PharmacyToDose PharmacyToDose.com PharmacyToDose@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
CRRT Trials of the Week: RENAL & IDEAL-ICU Special Guest: Linda Awdishu, PharmD, MAS Linda Awdishu joins me to highlight two landmark studies related to the use of continuous renal replacement therapy (CRRT) in the critically ill. We discuss renal replacement therapy, compare modalities, and review the history of CRRT as an introduction. Then we review two studies: “Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients: RENAL study” published in 2009 and “Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis: IDEAL-ICU study” published in 2018, both in the New England Journal of Medicine. Would these findings be replicated in other populations, do we have answers about the most appropriate effluent rate and when to initiate CRRT in the critically ill, findings from both studies, future research priorities, and much, much more! References list: https://pharmacytodose.files.wordpress.com/2023/10/crrt-tow-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Pulmonary Hypertension Part II Special Guest: Zach Smith, PharmD, BCPS, BCCCP, FCCP 04:03 – Intro/Diagnosis/Classification 14:30 – Treatment overview 24:00 – CCB 30:30 – PDE5i/ERA/GCS 40:00 – Prostacyclins 46:40 – RV failure in the ICU 64:30 – Role of PharmD/Take-home points Reference List: https://pharmacytodose.files.wordpress.com/2023/10/pulmonary-hypertension-part-ii-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
