How will we fight climate change? What are our plans to deal with rare diseases and future pandemics? What can we do to future-proof our food systems? The answers all lie in genomics, and Indigenous leaders are playing an important role in strengthening the research and solutions coming out of this field. As part of our Spotlight on the Future of Indigenous Genomics Innovation, this report sheds light on the important innovations happening in this scene and how Canada can make the most of this opportunity.