Johan Rockström and colleagues first proposed the concept in 2009 of planetary boundary threats and a safe operating space for humanity. This conceptual framework clarifies environmental problems that are of planetary significance, such as biodiversity loss, climate change, and stratospheric ozone depletion. The most recently articulated planetary boundary threat, or set of threats, relates to chemical pollution of the biosphere. With us to unpack planetary boundary threats as they relate to pollution is Bethanie Carney Almroth. Bethanie is a professor at the University of Gothenburg, where she researches threats posed to our planet due to the immense number and quantities of synthetic chemicals released into the environment.